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A blastocoel(e) or blastocele (also called blastocyst cavity,[1] cleavage cavity or segmentation cavity) is the fluid-filled central region of a blastocyst. A blastocoele forms during embryogenesis when a zygote (a fertilized ovum) divides into many cells through mitosis.

The adjectival of "blastocoel(e)" is blastocoelic.

A blastocoel can be described as the first cell cavity formed as the embryo enlarges. It is essential for later gastrulation.

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