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The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.^[1] This can either be DNA replication in living organisms such as prokaryotes and eukaryotes, or RNA replication in RNA viruses, such as double-stranded RNA viruses. DNA replication may proceed from this point bidirectionally or unidirectionally.

The specific structure of the origin of replication varies somewhat from species to species, but all share some common characteristics such as high AT content. The origin of replication binds the pre-replication complex, a protein complex that recognizes, unwinds, and begins to copy DNA.

The two types of replication origin are&_160;

There are also significant differences between prokaryotic and eukaryotic origins of replication

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