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Phlegm (pronounced /'flem/) is sticky fluid secreted by the mucous membranes of humans and other animals. Its definition is limited to the mucus produced by the respiratory system, excluding that from the nasal passages, and particularly that which is expelled by coughing (sputum). Its composition varies, depending on climate, genetics, and state of the immune system, but basically is a water-based gel consisting of glycoproteins, immunoglobulins, lipids, etc.

Phlegm may be of several different colors.

Phlegm may be a carrier of larvae of intestinal parasites (see hookworm). Bloody sputum can be a symptom of serious disease (such as tuberculosis and lung cancer), but can also be a relatively benign symptom of a minor disease (such as bronchitis). In the latter case, the sputum is normally lightly streaked with blood. Coughing up any significant quantity of blood is always a serious medical condition, and any person who experiences this should seek medical attention.

Phlegm was thought to be associated with apathetic behavior; this old belief is preserved in the word "phlegmatic".

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