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In physiology, tolerance occurs when an organism builds up a resistance to the effects of a substance after repeated exposure. This can occur with environmental substances such as salt or pesticides. It is also commonly encountered in pharmacology (see drug tolerance), when a subject's reaction to a drug (such as a painkiller or intoxicant) decreases so that larger doses are required to achieve the same effect. There are two major mechanisms for tolerance name="See_also" id="See_also">
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Physiological Tolerance Articles
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