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Prognosis (older Greek p?????s??, modern Greek p?????s? - literally fore-knowing, foreseeing) is a medical term denoting the doctor's prediction of how a patient's disease will progress, and whether there is chance of recovery. Since the 20th century, the word has been increasingly used in non-medical contexts as well, for example in corporate finance.

In medicine today, doctors search for methods of predicting how a patient (given their condition) may respond to treatment. Symptoms and tests may indicate favorable treatment with standard therapies. Likewise, a number of symptoms, health factors, and tests may indicate a less favorable treatment result with standard treatment - this may indicate that a more aggressive treatment plan may be desired.

Two areas where this type of prognosis prediction, or the use of prognostic indicators, is with Hodgkin's lymphoma and Non-Hodgkin lymphoma. Specifically with Non-Hodgkin lymphoma, physicians have developed the International Prognostic Index to predict patient outcome.

Prognostic scoring is also used for other cancer outcome predictions. A Manchester score is an indicator of prognosis in small cell lung cancer.

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