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Rous sarcoma virus is a retrovirus; a class VI enveloped virus with a positive sense RNA genome having a DNA intermediate. As with all retroviruses, it reverse transcribes its RNA genome into cDNA before integration into the host DNA. The RSV genome has terminal repeats enabling its integration into the host genome and also over expression of RSV genes. RSV was discovered in 1916 by Peyton Rous, working at Rockefeller University in New York City, by injecting cell free extract of chicken tumour into healthy chickens. The extract was found to induce oncogenesis in Plymouth Rock chickens. The tumour was found to be composed of connective tissue (a sarcoma).
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