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Toxicity Class refers to a classification system for pesticides created by a national or international government-related or -sponsored organization. It addresses the acute toxicity of agents such as soil fumigants, fungicides, herbicides, insecticides, miticides, molluscicides, nematicides, or rodenticides.

Assignment to a Toxicity Class is based typically on results of acute toxicity studies such as the determination of LD50 values in animal experiments, notably rodents, via oral, or sometimes inhaled, or external application. The experimental design measures the acute death rate of an agent. The Toxicity Class generally does not address issues of other potential harm of the agent, such as bioaccumulation, issues of carcinogenicity, teratogenicity, or mutagenic effects, or the impact on reproduction.

Regulating agencies may require that packaging of the agent is labeled with a Signal Word, a specific warning label to indicate the level of toxicity to the public.

The Environmental Protection Agency knows four Toxicity Classes. Class I to III are required to carry a Signal Word on the label to warn users of the toxicity. Pesticides are regulated by the Federal Insecticide, Fungicide, and Rodenticide Act(FIFRA).

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